STAPHYLOCOCCAL BICOMPONENT PORE-FORMING TOXINS: TARGETS FOR PROPHYLAXIS AND IMMUNOTHERAPY


Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer

Abstract Despite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear.Here, imaging mass cytometry of tumor tissues from ICB-treated patients identifies a distinct cell population of CD39+PD-1+CD8+ T cells, specifically the TCF1+ subset,

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Letters of Marcus Antonius Kappus from colonial America VI

This is the sixth - and also the last - in the present series of letters which Marcus Antonius Kappus ( 1657 - 1717, since 1687 Jesuitic missionary in the colonial Sonora) had sent to his relatives and acquaintances in Slovenia that have been preserved to the present day.Of the five letters which CINNAMON BARK we have published so far, two were wri

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